2017

myVCF: a desktop application for high-throughput mutations data management.
Pietrelli A, Valenti L.
Bioinformatics (2017). 33(22):3676-3678.

TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut.
Romagnani A, Vettore V, Rezzonico-Jost T, Hampe S, Rottoli E, Nadolni W, Perotti M, Meier MA, Hermanns C, Geiger S, Wennemuth G, Recordati C, Matsushita M, Muehlich S, Proietti M, Chubanov V, Gudermann T, Grassi F, Zierler S.
Nat Commun. (2017). 8(1):1917.

TCTN2: a novel tumor marker with oncogenic properties.
Cano-Rodriguez D, Campagnoli S, Grandi A, Parri M, Camilli E, Song C, Jin B, Lacombe A, Pierleoni A, Bombaci M, Cordiglieri C, Ruiters MH, Viale G, Terracciano L, Sarmientos P, Abrignani S, Grandi G, Pileri P, Rots MG, Grifantini R.
Oncotarget. (2017).8(56):95256-95269.

Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation.
Cariulo C, Azzollini L, Verani M, Martufi P, Boggio R, Chiki A, Deguire SM, Cherubini M, Gines S, Marsh JL, Conforti P, Cattaneo E, Santimone I, Squitieri F, Lashuel HA, Petricca L, Caricasole A
Proc Natl Acad Sci U S A. (2017). 114(50):E10809-E10818.

Crosstalks between translation and metabolism in cancer.
Biffo S, Manfrini N, Ricciardi S.
Curr Opin Genet Dev. (2017) 48:75-81.

FGF2 and EGF Are Required for Self-Renewal and Organoid Formation of Canine Normal and Tumor Breast Stem Cells.

Cocola C, Molgora S, Piscitelli E, Veronesi MC, Greco M, Bragato C, Moro M, Crosti M, Gray B, Milanesi L, Grieco V, Luvoni GC, Kehler J, Bellipanni G, Reinbold R, Zucchi I, Giordano A
J Cell Biochem. (2017); 118:570-584.

The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks.
Clarke K, Ricciardi S, Pearson T, Bharudin I, Davidsen PK, Bonomo M, Brina D, Scagliola A, Simpson DM, Beynon RJ, Khanim F, Ankers J, Sarzynski MA, Ghosh S, Pisconti A, Rozman J, Hrabe de Angelis M, Bunce C, Stewart C, Egginton S, Caddick M, Jackson M, Bouchard C, Biffo S, Falciani F
Cell Rep. (2017) 21:1507-1520.

Guidelines for the use of flow cytometry and cell sorting in immunological studies.
Cossarizza A, Chang HD, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Dreher A, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Geginat J, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mirrer D, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O’Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruckert B, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J.
Eur J Immunol (2017) 47:1584-1797

Repression of miR-31 by BCL6 stabilizes the helper function of human follicular helper T cells.
Ripamonti A, Provasi E, Lorenzo M, De Simone M, Ranzani V, Vangelisti S, Curti S, Bonnal RJP, Pignataro L, Torretta S, Geginat J, Rossetti G, Pagani M, Abrignani S.
Proc Natl Acad Sci U S A. (2017) 114:12797-12802

Maintenance of memory CD8 T cells: Divided over division.
Nolte MA, Goedhart M, Geginat J.
Eur J Immunol. (2017) 47:1875-1879

CD4+ T Helper Cell Plasticity in Infection, Inflammation, and Autoimmunity.
Huber S, Gagliani N, O’Connor W Jr, Geginat J, Caprioli F.
Mediators Inflamm. 2017;2017:7083153

NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains.
Benzine T, Brandt R, Lovell WC, Yamane D, Neddermann P, De Francesco R, Lemon SM, Perelson AS, Ke R, McGivern DR.
PLoS Pathog (2017) 13:e1006343

A cytosolic Ezh1 isoform modulates a PRC2-Ezh1 epigenetic adaptive response in postmitotic cells.
Bodega B, Marasca F, Ranzani V, Cherubini A, Della Valle F, Neguembor MV, Wassef M, Zippo A, Lanzuolo C, Pagani M, Orlando V.
Nat Struct Mol Biol (2017) 24:444-452

SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention.
Calamita P, Miluzio A, Russo A, Pesce E, Ricciardi S, Khanim F, Cheroni C, Alfieri R, Mancino M, Gorrini C, Rossetti G, Peluso I, Pagani M, Medina DL, Rommens J, Biffo S.
PLoS Genet (2017) 13:e1006552

Improvement of ALT decay kinetics by all-oral HCV treatment: Role of NS5A inhibitors and differences with IFN-based regimens.
Cento V, Nguyen THT, Di Carlo D, Biliotti E, Gianserra L, Lenci I, Di Paolo D, Calvaruso V, Teti E, Cerrone M, Romagnoli D, Melis M, Danieli E, Menzaghi B, Polilli E, Siciliano M, Nicolini LA, Di Biagio A, Magni CF, Bolis M, Antonucci FP, Di Maio VC, Alfieri R, Sarmati L, Casalino P, Bernardini S, Micheli V, Rizzardini G, Parruti G, Quirino T, Puoti M, Babudieri S, D’Arminio Monforte A, Andreoni M, Craxi A, Angelico M, Pasquazzi C, Taliani G, Guedj J, Perno CF, Ceccherini-Silberstein F.
PLoS One (2017) 12:e0177352

Eukaryotic initiation factor eIF6 modulates the expression of Kermit 2/XGIPC in IGF- regulated eye development.
De Marco N, Tussellino M, Carotenuto R, Ronca R, Rizzolio S, Biffo S, Campanella C.
Dev Biol (2017) 427:148-154

Telomerase reverse transcriptase germline mutations and hepatocellular carcinoma in patients with nonalcoholic fatty liver disease.
Donati B, Pietrelli A, Pingitore P, Dongiovanni P, Caddeo A, Walker L, Baselli G, Pelusi S, Rosso C, Vanni E, Daly A, Mancina RM, Grieco A, Miele L, Grimaudo S, Craxi A, Petta S, De Luca L, Maier S, Soardo G, Bugianesi E, Colli F, Romagnoli R, Anstee QM, Reeves HL, Fracanzani AL, Fargion S, Romeo S, Valenti L.
Cancer Med (2017) 6:1930-1940

Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.
Dongiovanni P, Meroni M, Baselli GA, Bassani GA, Rametta R, Pietrelli A, Maggioni M, Facciotti F, Trunzo V, Badiali S, Fargion S, Gatti S, Valenti L.
Clin Sci (Lond) (2017) 131:1301-1315

Differentiation of human telencephalic progenitor cells into MSNs by inducible expression of Gsx2 and Ebf1.
Faedo A, Laporta A, Segnali A, Galimberti M, Besusso D, Cesana E, Belloli S, Moresco RM, Tropiano M, Fuca E, Wild S, Bosio A, Vercelli AE, Biella G, Cattaneo E.
Proc Natl Acad Sci U S A (2017) 114:E1234-E1242

Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells.
Fagnocchi L, Zippo A.
Front Cell Dev Biol (2017) 5:7

MicroRNA-26a/cyclin-dependent kinase 5 axis controls proliferation, apoptosis and in vivo tumor growth of diffuse large B-cell lymphoma cell lines.
Farina FM, Inguscio A, Kunderfranco P, Cortesi A, Elia L, Quintavalle M.
Cell Death Dis (2017) 8:e2890

Lack of evidence for post-vaccine onset of autoimmune/lymphoproliferative disorders, during a nine-month follow-up in multiply vaccinated Italian military personnel.
Ferlito C, Barnaba V, Abrignani S, Bombaci M, Sette A, Sidney J, Biselli R, Tomao E, Cattaruzza MS, Germano V, Biondo MI, Salerno G, Lulli P, Caporuscio S, Picchianti Diamanti A, Falco M, Biselli V, Cardelli P, Autore A, Lucertini E, De Cesare DP, Peragallo MS, Lista F, Martire C, Salemi S, Nisini R, D’Amelio R.
Clin Immunol (2017) 181:60-66

Immunological phenotype of the murine Lrba knockout.
Gamez-Diaz L, Neumann J, Jager F, Proietti M, Felber F, Soulas-Sprauel P, Perruzza L, Grassi F, Kogl T, Aichele P, Kilimann M, Grimbacher B, Jung S.
Immunol Cell Biol (2017) 95:789-802

The Enigmatic Role of Viruses in Multiple Sclerosis: Molecular Mimicry or Disturbed Immune Surveillance?
Geginat J, Paroni M, Pagani M, Galimberti D, De Francesco R, Scarpini E, Abrignani S.
Trends Immunol (2017) 38:498-512

Purification of LAT-Containing Membranes from Resting and Activated T Lymphocytes.
Hivroz C, Larghi P, Jouve M, Ardouin L.
Methods Mol Biol (2017) 1584:355-368

The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets.
Iaconis D, Monti M, Renda M, van Koppen A, Tammaro R, Chiaravalli M, Cozzolino F, Pignata P, Crina C, Pucci P, Boletta A, Belcastro V, Giles RH, Surace EM, Gallo S, Pende M, Franco B.
Sci Rep (2017) 7:1224

Analysis of T Cell Activation by Confocal Microscopy.
Larghi P, Viola A, Molon B.
Methods Mol Biol (2017) 1514:63-81

Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation.
Manfrini N, Ricciardi S, Miluzio A, Fedeli M, Scagliola A, Gallo S, Adler T, Busch DH, Gailus-Durner V, Fuchs H, de Angelis MH, Biffo S.
Data Brief (2017) 14:653-658

High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans.
Manfrini N, Ricciardi S, Miluzio A, Fedeli M, Scagliola A, Gallo S, Brina D, Adler T, Busch DH, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Biffo S.
Dev Comp Immunol (2017) 77:69-76

CombiROC: an interactive web tool for selecting accurate marker combinations of omics data.
Mazzara S, Rossi RL, Grifantini R, Donizetti S, Abrignani S, Bombaci M.
Sci Rep (2017) 7:45477

Filamin A is reduced and contributes to the CASR sensitivity in human parathyroid tumors.
Mingione A, Verdelli C, Ferrero S, Vaira V, Guarnieri V, Scillitani A, Vicentini L, Balza G, Beretta E, Terranegra A, Vezzoli G, Soldati L, Corbetta S.
J Mol Endocrinol (2017) 58:91-103

Role of microRNAs in translation regulation and cancer.
Oliveto S, Mancino M, Manfrini N, Biffo S.
World J Biol Chem (2017) 8:45-56

Recognition of viral and self-antigens by TH1 and TH1/TH17 central memory cells in patients with multiple sclerosis reveals distinct roles in immune surveillance and relapses.
Paroni M, Maltese V, De Simone M, Ranzani V, Larghi P, Fenoglio C, Pietroboni AM, De Riz MA, Crosti MC, Maglie S, Moro M, Caprioli F, Rossi R, Rossetti G, Galimberti D, Pagani M, Scarpini E, Abrignani S, Geginat J.
J Allergy Clin Immunol (2017) 140:797-808

Differences in serum and synovial CD4+ T cells and cytokine profiles to stratify patients with inflammatory osteoarthritis and rheumatoid arthritis.
Penatti A, Facciotti F, De Matteis R, Larghi P, Paroni M, Murgo A, De Lucia O, Pagani M, Pierannunzii L, Truzzi M, Ioan-Facsinay A, Abrignani S, Geginat J, Meroni PL.
Arthritis Res Ther (2017) 19:103

T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP.
Perruzza L, Gargari G, Proietti M, Fosso B, D’Erchia AM, Faliti CE, Rezzonico-Jost T, Scribano D, Mauri L, Colombo D, Pellegrini G, Moregola A, Mooser C, Pesole G, Nicoletti M, Norata GD, Geuking MB, McCoy KD, Guglielmetti S, Grassi F.
Cell Rep (2017) 18:2566-2575

Dopamine receptor type 2 (DRD2) and somatostatin receptor type 2 (SSTR2) agonists are effective in inhibiting proliferation of progenitor/stem-like cells isolated from nonfunctioning pituitary tumors.
Peverelli E, Giardino E, Treppiedi D, Meregalli M, Belicchi M, Vaira V, Corbetta S, Verdelli C, Verrua E, Serban AL, Locatelli M, Carrabba G, Gaudenzi G, Malchiodi E, Cassinelli L, Lania AG, Ferrero S, Bosari S, Vitale G, Torrente Y, Spada A, Mantovani G.
Int J Cancer (2017) 140:1870-1880

Nuclear Localization of Diacylglycerol Kinase Alpha in K562 Cells Is Involved in Cell Cycle Progression.
Poli A, Fiume R, Baldanzi G, Capello D, Ratti S, Gesi M, Manzoli L, Graziani A, Suh PG, Cocco L, Follo MY.
J Cell Physiol (2017) 232:2550-2557

Nuclear translocation of PKC-alpha is associated with cell cycle arrest and erythroid differentiation in myelodysplastic syndromes (MDSs).
Poli A, Ratti S, Finelli C, Mongiorgi S, Clissa C, Lonetti A, Cappellini A, Catozzi A, Barraco M, Suh PG, Manzoli L, McCubrey JA, Cocco L, Follo MY.
FASEB J (2017)

Next-Generation Sequencing Analysis of Long Noncoding RNAs in CD4+ T Cell Differentiation.
Ranzani V, Arrigoni A, Rossetti G, Panzeri I, Abrignani S, Bonnal RJ, Pagani M.
Methods Mol Biol (2017) 1514:173-185

Human macrophage ferroportin biology and the basis for the ferroportin disease.
Sabelli M, Montosi G, Garuti C, Caleffi A, Oliveto S, Biffo S, Pietrangelo A.
Hepatology (2017) 65:1512-1525

Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity.
Torri A, Carpi D, Bulgheroni E, Crosti MC, Moro M, Gruarin P, Rossi RL, Rossetti G, Di Vizio D, Hoxha M, Bollati V, Gagliani C, Tacchetti C, Paroni M, Geginat J, Corti L, Venegoni L, Berti E, Pagani M, Matarese G, Abrignani S, de Candia P.
J Biol Chem (2017) 292:2903-2915

 

 

 

 

 

2016

miR-17∼92 family clusters control iNKT cell ontogenesis via modulation of TGF-β signaling.
Fedeli M, Riba M, Garcia Manteiga JM, Tian L, Viganò V, Rossetti G, Pagani M, Xiao C, Liston A, Stupka E, Cittaro D, Abrignani S, Provero P, Dellabona P, Casorati G
Proc Natl Acad Sci U S A. (2016). 113(51):E8286-E8295.

 

The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery.
Stunnenberg HG; International Human Epigenome Consortium, Hirst M.
Cell. (2016); 167(7):1897.

Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.
Bedogni F, Cobolli Gigli C, Pozzi D, Rossi RL, Scaramuzza L, Rossetti G, Pagani M, Kilstrup-Nielsen C, Matteoli M, Landsberger N.
Cereb Cortex. (2016). (6):2517-2529.

In-Vivo Validation of Fully Implantable Multi-Panel Devices for Remote Monitoring of Metabolism.
Baj-Rossi C, Cavallini A, Kilinc EG, Stradolini F, Rezzonico Jost T, Proietti M, De Micheli G, Grassi F, Dehollain C, Carrara S.
IEEE Trans Biomed Circuits Syst. (2016) doi: 10.1109/TBCAS.2016.2584239. [Epub ahead of print]

Determination of Polycomb Group of Protein Compartmentalization Through Chromatin Fractionation Procedure.
Marasca F, Marullo F, Lanzuolo C
Methods Mol Biol. (2016);1480:167-80.

Analysis RNA-seq and Noncoding RNA.
Arrigoni A, Ranzani V, Rossetti G, Panzeri I, Abrignani S, Bonnal RJ, Pagani M.
Methods Mol Biol (2016) 1480:125-35

FALDO: a semantic standard for describing the location of nucleotide and protein feature annotation.
Bolleman JT, Mungall CJ, Strozzi F, Baran J, Dumontier M, Bonnal RJ, Buels R, Hoehndorf R, Fujisawa T, Katayama T, Cock PJ.
J Biomed Semantics (2016) 7:39

DEPDC5 variants increase fibrosis progression in Europeans with chronic hepatitis C virus infection.
Burza MA, Motta BM, Mancina RM, Pingitore P, Pirazzi C, Lepore SM, Spagnuolo R, Doldo P, Russo C, Lazzaro V, Fischer J, Berg T, Aghemo A, Cheroni C, De Francesco R, Fargion S, Colombo M, Datz C, Stickel F, Valenti L, Romeo S.
Hepatology (2016) 63:418-27

A neuronal network of mitochondrial dynamics regulates metastasis.
Caino MC, Seo JH, Aguinaldo A, Wait E, Bryant KG, Kossenkov AV, Hayden JE, Vaira V, Morotti A, Ferrero S, Bosari S, Gabrilovich DI, Languino LR, Cohen AR, Altieri DC.
Nat Commun (2016) 7:13730

Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming.
Chae YC, Vaira V, Caino MC, Tang HY, Seo JH, Kossenkov AV, Ottobrini L, Martelli C, Lucignani G, Bertolini I, Locatelli M, Bryant KG, Ghosh JC, Lisanti S, Ku B, Bosari S, Languino LR, Speicher DW, Altieri DC.
Cancer Cell (2016) 30:257-272

Fluorescence Resonance Energy Transfer Microscopy for Measuring Chromatin Complex Structure and Dynamics.
Cherubini A, Zippo A.
Methods Mol Biol (2016) 1480:143-52

The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells.
Chiaruttini G, Piperno GM, Jouve M, De Nardi F, Larghi P, Peden AA, Baj G, Muller S, Valitutti S, Galli T, Benvenuti F.
Cell Rep (2016) 14:2624-36

Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer.
Ciardiello C, Cavallini L, Spinelli C, Yang J, Reis-Sobreiro M, de Candia P, Minciacchi VR, Di Vizio D.
Int J Mol Sci (2016) 17:175

Chromosome Conformation Capture in Primary Human Cells.
Cortesi A, Bodega B.
Methods Mol Biol (2016) 1480:213-21

The circulating microRNome demonstrates distinct lymphocyte subset-dependent signatures.
de Candia P, Torri A, Fedeli M, Vigano V, Carpi D, Gorletta T, Casorati G, Pagani M, Dellabona P, Abrignani S.
Eur J Immunol (2016) 46:725-31

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells.
De Simone M, Arrigoni A, Rossetti G, Gruarin P, Ranzani V, Politano C, Bonnal RJ, Provasi E, Sarnicola ML, Panzeri I, Moro M, Crosti M, Mazzara S, Vaira V, Bosari S, Palleschi A, Santambrogio L, Bovo G, Zucchini N, Totis M, Gianotti L, Cesana G, Perego RA, Maroni N, Pisani Ceretti A, Opocher E, De Francesco R, Geginat J, Stunnenberg HG, Abrignani S, Pagani M.
Immunity (2016) 45:1135-1147

Analysis of NSCLC tumour heterogeneity, proliferative and 18F-FDG PET indices reveals Ki67 prognostic role in adenocarcinomas.
Del Gobbo A, Pellegrinelli A, Gaudioso G, Castellani M, Zito Marino F, Franco R, Palleschi A, Nosotti M, Bosari S, Vaira V, Ferrero S.
Histopathology (2016) 68:746-51

Phosphoinositides in the nucleus and myogenic differentiation: how a nuclear turtle with a PHD builds muscle.
Divecha N.
Biochem Soc Trans (2016) 44:299-306

The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage.
Donati B, Motta BM, Pingitore P, Meroni M, Pietrelli A, Alisi A, Petta S, Xing C, Dongiovanni P, del Menico B, Rametta R, Mancina RM, Badiali S, Fracanzani AL, Craxi A, Fargion S, Nobili V, Romeo S, Valenti L.
Hepatology (2016) 63:787-98

Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIalpha and Oxysterol-Binding Protein.
Dorobantu CM, Albulescu L, Lyoo H, van Kampen M, De Francesco R, Lohmann V, Harak C, van der Schaar HM, Strating JR, Gorbalenya AE, van Kuppeveld FJ.
mSphere (2016) 1

IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus.
Facciotti F, Gagliani N, Haringer B, Alfen JS, Penatti A, Maglie S, Paroni M, Iseppon A, Moro M, Crosti MC, Stolzel K, Romagnani C, Moroni G, Ingegnoli F, Torretta S, Pignataro L, Annoni A, Russo F, Pagani M, Abrignani S, Meroni P, Flavell R, Geginat J.
J Allergy Clin Immunol (2016) 137:318-321 e5

A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity.
Fagnocchi L, Cherubini A, Hatsuda H, Fasciani A, Mazzoleni S, Poli V, Berno V, Rossi RL, Reinbold R, Endele M, Schroeder T, Rocchigiani M, Szkarlat Z, Oliviero S, Dalton S, Zippo A.
Nat Commun (2016) 7:11903

Integration of Signaling Pathways with the Epigenetic Machinery in the Maintenance of Stem Cells.
Fagnocchi L, Mazzoleni S, Zippo A.
Stem Cells Int (2016) 2016:8652748

Ectonucleotidase activity and immunosuppression in astrocyte-CD4 T cell bidirectional signaling.
Filipello F, Pozzi D, Proietti M, Romagnani A, Mazzitelli S, Matteoli M, Verderio C, Grassi F.
Oncotarget (2016) 7:5143-56

PIP4K2B: Coupling GTP Sensing to PtdIns5P Levels to Regulate Tumorigenesis.
Fiume R, Jones DR, Divecha N.
Trends Biochem Sci (2016) 41:473-475

The light and the dark sides of Interleukin-10 in immune-mediated diseases and cancer.
Geginat J, Larghi P, Paroni M, Nizzoli G, Penatti A, Pagani M, Gagliani N, Meroni P, Abrignani S, Flavell RA.
Cytokine Growth Factor Rev (2016) 30:87-93

Reverse plasticity: TGF-beta and IL-6 induce Th1-to-Th17-cell transdifferentiation in the gut.
Geginat J, Paroni M, Kastirr I, Larghi P, Pagani M, Abrignani S.
Eur J Immunol (2016) 46:2306-2310

ERMP1, a novel potential oncogene involved in UPR and oxidative stress defense, is highly expressed in human cancer.
Grandi A, Santi A, Campagnoli S, Parri M, De Camilli E, Song C, Jin B, Lacombe A, Castori-Eppenberger S, Sarmientos P, Grandi G, Viale G, Terracciano L, Chiarugi P, Pileri P, Grifantini R.
Oncotarget (2016) 7:63596-63610

An Automatic Segmentation Method Combining an Active Contour Model and a Classification Technique for Detecting Polycomb-group Proteinsin High-Throughput Microscopy Images.
Gregoretti F, Cesarini E, Lanzuolo C, Oliva G, Antonelli L.
Methods Mol Biol (2016) 1480:181-97

Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.
Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S, Neumann-Haefelin C, Thimme R, Meuleman P, Vondran FW, Francesco R, Rice CM, Bartenschlager R, Lohmann V.
Nat Microbiol (2016) 2:16247

Role of CXCR4-mediated bone marrow colonization in CNS infiltration by T cell acute lymphoblastic leukemia.
Jost TR, Borga C, Radaelli E, Romagnani A, Perruzza L, Omodho L, Cazzaniga G, Biondi A, Indraccolo S, Thelen M, Te Kronnie G, Grassi F.
J Leukoc Biol (2016) 99:1077-87

Platelet-derived growth factor-alpha receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer.
Kabanova A, Marcandalli J, Zhou T, Bianchi S, Baxa U, Tsybovsky Y, Lilleri D, Silacci-Fregni C, Foglierini M, Fernandez-Rodriguez BM, Druz A, Zhang B, Geiger R, Pagani M, Sallusto F, Kwong PD, Corti D, Lanzavecchia A, Perez L.
Nat Microbiol (2016) 1:16082

Normalization of circulating microRNA expression data obtained by quantitative real-time RT-PCR.
Marabita F, de Candia P, Torri A, Tegner J, Abrignani S, Rossi RL.
Brief Bioinform (2016) 17:204-12

The Adipose Mesenchymal Stem Cell Secretome Inhibits Inflammatory Responses of Microglia: Evidence for an Involvement of Sphingosine-1-Phosphate Signalling.
Marfia G, Navone SE, Hadi LA, Paroni M, Berno V, Beretta M, Gualtierotti R, Ingegnoli F, Levi V, Miozzo M, Geginat J, Fassina L, Rampini P, Tremolada C, Riboni L, Campanella R.
Stem Cells Dev (2016) 25:1095-107

Nucleoplasmic Lamin A/C and Polycomb group of proteins: An evolutionarily conserved interplay.
Marullo F, Cesarini E, Antonelli L, Gregoretti F, Oliva G, Lanzuolo C.
Nucleus (2016) 7:103-11

Translational control by mTOR-independent routes: how eIF6 organizes metabolism.
Miluzio A, Ricciardi S, Manfrini N, Alfieri R, Oliveto S, Brina D, Biffo S.
Biochem Soc Trans (2016) 44:1667-1673

CDKL5 and Shootin1 Interact and Concur in Regulating Neuronal Polarization.
Nawaz MS, Giarda E, Bedogni F, La Montanara P, Ricciardi S, Ciceri D, Alberio T, Landsberger N, Rusconi L, Kilstrup-Nielsen C.
PLoS One (2016) 11:e0148634

IL-10 promotes homeostatic proliferation of human CD8(+) memory T cells and, when produced by CD1c(+) DCs, shapes naive CD8(+) T-cell priming.
Nizzoli G, Larghi P, Paroni M, Crosti MC, Moro M, Neddermann P, Caprioli F, Pagani M, De Francesco R, Abrignani S, Geginat J.
Eur J Immunol (2016) 46:1622-32

Uncontrolled IL-17 Production by Intraepithelial Lymphocytes in a Case of non-IPEX Autoimmune Enteropathy.
Paroni M, Magarotto A, Tartari S, Nizzoli G, Larghi P, Ercoli G, Gianelli U, Pagani M, Elli L, Abrignani S, Conte D, Geginat J, Caprioli F.
Clin Transl Gastroenterol (2016) 7:e182

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex.
Pema M, Drusian L, Chiaravalli M, Castelli M, Yao Q, Ricciardi S, Somlo S, Qian F, Biffo S, Boletta A.
Nat Commun (2016) 7:10786

Dopamine receptor type 2 (DRD2) inhibits migration and invasion of human tumorous pituitary cells through ROCK-mediated cofilin inactivation.
Peverelli E, Giardino E, Treppiedi D, Locatelli M, Vaira V, Ferrero S, Bosari S, Lania AG, Spada A, Mantovani G.
Cancer Lett (2016) 381:279-86

Role of Strain Rate in the Pathogenesis of Ventilator-Induced Lung Edema.
Protti A, Maraffi T, Milesi M, Votta E, Santini A, Pugni P, Andreis DT, Nicosia F, Zannin E, Gatti S, Vaira V, Ferrero S, Gattinoni L
Crit Care Med (2016) 44:e838-45

Protein O-mannosylation is crucial for human mesencyhmal stem cells fate.
Ragni E, Lommel M, Moro M, Crosti M, Lavazza C, Parazzi V, Saredi S, Strahl S, Lazzari L.
Cell Mol Life Sci (2016) 73:445-58

Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects.
Rigoni R, Fontana E, Guglielmetti S, Fosso B, D’Erchia AM, Maina V, Taverniti V, Castiello MC, Mantero S, Pacchiana G, Musio S, Pedotti R, Selmi C, Mora JR, Pesole G, Vezzoni P, Poliani PL, Grassi F, Villa A, Cassani B.
J Exp Med (2016) 213:355-75

RAGs and BUGS: An alliance for autoimmunity.
Rigoni R, Grassi F, Villa A, Cassani B.
Gut Microbes (2016) 7:503-511

 

 

 

 

 

2015

Daclatasvir: a team player rather than a prima donna in the treatment of hepatitis C.
Aghemo A, De Francesco R.
Gut (2015) 64:860-2

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.
Arner E, Daub CO, Vitting-Seerup K, Andersson R, Lilje B, Drablos F, Lennartsson A, Ronnerblad M, Hrydziuszko O, Vitezic M, Freeman TC, Alhendi AM, Arner P, Axton R, Baillie JK, Beckhouse A, Bodega B, Briggs J, Brombacher F, Davis M, Detmar M, Ehrlund A, Endoh M, Eslami A, Fagiolini M, Fairbairn L, Faulkner GJ, Ferrai C, Fisher ME, Forrester L, Goldowitz D, Guler R, Ha T, Hara M, Herlyn M, Ikawa T, Kai C, Kawamoto H, Khachigian LM, Klinken SP, Kojima S, Koseki H, Klein S, Mejhert N, Miyaguchi K, Mizuno Y, Morimoto M, Morris KJ, Mummery C, Nakachi Y, Ogishima S, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov D, Passier R, Patrikakis M, Pombo A, Qin XY, Roy S, Sato H, Savvi S, Saxena A, Schwegmann A, Sugiyama D, Swoboda R, Tanaka H, Tomoiu A, Winteringham LN, Wolvetang E, Yanagi-Mizuochi C, Yoneda M, Zabierowski S, Zhang P, Abugessaisa I, Bertin N, Diehl AD, Fukuda S, Furuno M, Harshbarger J, Hasegawa A, Hori F, Ishikawa-Kato S, Ishizu Y, Itoh M, Kawashima T, Kojima M, Kondo N, Lizio M, Meehan TF, Mungall CJ, Murata M, Nishiyori-Sueki H, Sahin S, Nagao-Sato S, Severin J, de Hoon MJ, Kawai J, Kasukawa T, Lassmann T, Suzuki H, Kawaji H, Summers KM, Wells C, Consortium F, Hume DA, Forrest AR, Sandelin A, Carninci P, Hayashizaki Y.
Science (2015) 347:1010-4

Dissection of the cord blood stromal component reveals predictive parameters for culture outcome.
Barilani M, Lavazza C, Vigano M, Montemurro T, Boldrin V, Parazzi V, Montelatici E, Crosti M, Moro M, Giordano R, Lazzari L.
Stem Cells Dev (2015) 24:104-14

G-Force PD: a global initiative in coordinating stem cell-based dopamine treatments for Parkinson’s disease.
Barker RA, Studer L, Cattaneo E, Takahashi J, consortium GFP.
NPJ Parkinsons Dis (2015) 1:15017

De novo transcriptome profiling of highly purified human lymphocytes primary cells.
Bonnal RJ, Ranzani V, Arrigoni A, Curti S, Panzeri I, Gruarin P, Abrignani S, Rossetti G, Pagani M.
Sci Data (2015) 2:150051

miRiadne: a web tool for consistent integration of miRNA nomenclature.
Bonnal RJ, Rossi RL, Carpi D, Ranzani V, Abrignani S, Pagani M.
Nucleic Acids Res (2015) 43:W487-92

eIF6 anti-association activity is required for ribosome biogenesis, translational control and tumor progression.
Brina D, Miluzio A, Ricciardi S, Biffo S.
Biochim Biophys Acta (2015) 1849:830-5

eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.
Brina D, Miluzio A, Ricciardi S, Clarke K, Davidsen PK, Viero G, Tebaldi T, Offenhauser N, Rozman J, Rathkolb B, Neschen S, Klingenspor M, Wolf E, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Quattrone A, Falciani F, Biffo S.
Nat Commun (2015) 6:8261

Gaps in knowledge and prospects for research of adjuvanted vaccines.
Seder R, Reed SG, O’Hagan D, Malyala P, D’Oro U, Laera D, Abrignani S, Cerundolo V, Steinman L, Bertholet S
Vaccine (2015) 33 Suppl 2:B40-3

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion.
Caino MC, Ghosh JC, Chae YC, Vaira V, Rivadeneira DB, Faversani A, Rampini P, Kossenkov AV, Aird KM, Zhang R, Webster MR, Weeraratna AT, Bosari S, Languino LR, Altieri DC.
Proc Natl Acad Sci U S A (2015) 112:8638-43

Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes.
Cesarini E, Mozzetta C, Marullo F, Gregoretti F, Gargiulo A, Columbaro M, Cortesi A, Antonelli L, Di Pelino S, Squarzoni S, Palacios D, Zippo A, Bodega B, Oliva G, Lanzuolo C.
J Cell Biol (2015) 211:533-51

Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity.
Cheroni C, Donnici L, Aghemo A, Balistreri F, Bianco A, Zanoni V, Pagani M, Soffredini R, D’Ambrosio R, Rumi MG, Colombo M, Abrignani S, Neddermann P, De Francesco R.
PLoS One (2015) 10:e0138546

Systematic comparison of single-chain Fv antibody-fusion toxin constructs containing Pseudomonas Exotoxin A or saporin produced in different microbial expression systems.
Della Cristina P, Castagna M, Lombardi A, Barison E, Tagliabue G, Ceriotti A, Koutris I, Di Leandro L, Giansanti F, Vago R, Ippoliti R, Flavell SU, Flavell DJ, Colombatti M, Fabbrini MS.
Microb Cell Fact (2015) 14:19

The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma.
Di Cristofori A, Ferrero S, Bertolini I, Gaudioso G, Russo MV, Berno V, Vanini M, Locatelli M, Zavanone M, Rampini P, Vaccari T, Caroli M, Vaira V.
Oncotarget (2015) 6:17514-31

The calcineurin-NFAT pathway controls activity-dependent circadian gene expression in slow skeletal muscle.
Dyar KA, Ciciliot S, Tagliazucchi GM, Pallafacchina G, Tothova J, Argentini C, Agatea L, Abraham R, Ahdesmaki M, Forcato M, Bicciato S, Schiaffino S, Blaauw B.
Mol Metab (2015) 4:823-33

Deregulation of MiR-34b/Sox2 Predicts Prostate Cancer Progression.
Forno I, Ferrero S, Russo MV, Gazzano G, Giangiobbe S, Montanari E, Del Nero A, Rocco B, Albo G, Languino LR, Altieri DC, Vaira V, Bosari S.
PLoS One (2015) 10:e0130060

The Contrasting Role of p16Ink4A Patterns of Expression in Neuroendocrine and Non-Neuroendocrine Lung Tumors: A Comprehensive Analysis with Clinicopathologic and Molecular Correlations.
Fusco N, Guerini-Rocco E, Del Gobbo A, Franco R, Zito-Marino F, Vaira V, Bulfamante G, Ercoli G, Nosotti M, Palleschi A, Bosari S, Ferrero S.
PLoS One (2015) 10:e0144923

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.
Gagliani N, Amezcua Vesely MC, Iseppon A, Brockmann L, Xu H, Palm NW, de Zoete MR, Licona-Limon P, Paiva RS, Ching T, Weaver C, Zi X, Pan X, Fan R, Garmire LX, Cotton MJ, Drier Y, Bernstein B, Geginat J, Stockinger B, Esplugues E, Huber S, Flavell RA.
Nature (2015) 523:221-5

Working hard at the nexus between cell signaling and the ribosomal machinery: An insight into the roles of RACK1 in translational regulation.
Gallo S, Manfrini N.
Translation (Austin) (2015) 3:e1120382

Immunity to Pathogens Taught by Specialized Human Dendritic Cell Subsets.
Geginat J, Nizzoli G, Paroni M, Maglie S, Larghi P, Pascolo S, Abrignani S.
Front Immunol (2015) 6:527

Adaptive mitochondrial reprogramming and resistance to PI3K therapy.
Ghosh JC, Siegelin MD, Vaira V, Faversani A, Tavecchio M, Chae YC, Lisanti S, Rampini P, Giroda M, Caino MC, Seo JH, Kossenkov AV, Michalek RD, Schultz DC, Bosari S, Languino LR, Altieri DC.
J Natl Cancer Inst (2015) 107

Signal Strength and Metabolic Requirements Control Cytokine-Induced Th17 Differentiation of Uncommitted Human T Cells.
Kastirr I, Crosti M, Maglie S, Paroni M, Steckel B, Moro M, Pagani M, Abrignani S, Geginat J.
J Immunol (2015) 195:3617-27

Two of Them Do It Better: Novel Serum Biomarkers Improve Autoimmune Hepatitis Diagnosis.
Mazzara S, Sinisi A, Cardaci A, Rossi RL, Muratori L, Abrignani S, Bombaci M.
PLoS One (2015) 10:e0137927

Transmembrane 6 superfamily member 2 gene E167K variant impacts on steatosis and liver damage in chronic hepatitis C patients.
Milano M, Aghemo A, Mancina RM, Fischer J, Dongiovanni P, De Nicola S, Fracanzani AL, D’Ambrosio R, Maggioni M, De Francesco R, Fargion S, Berg T, Stickel F, Hampe J, Romeo S, Colombo M, Valenti L.
Hepatology (2015) 62:111-7

Expression and activity of eIF6 trigger malignant pleural mesothelioma growth in vivo.
Miluzio A, Oliveto S, Pesce E, Mutti L, Murer B, Grosso S, Ricciardi S, Brina D, Biffo S.
Oncotarget (2015) 6:37471-85

Epigenetic alterations in cancer and personalized cancer treatment.
Miozzo M, Vaira V, Sirchia SM.
Future Oncol (2015) 11:333-48

Reference proteome of highly purified human Th1 cells reveals strong effects on metabolism and protein ubiquitination upon differentiation.
Pagani M, Rockstroh M, Schuster M, Rossetti G, Moro M, Crosti M, Tomm JM.
Proteomics (2015) 15:3644-7

Long Intergenic Non-Coding RNAs: Novel Drivers of Human Lymphocyte Differentiation.
Panzeri I, Rossetti G, Abrignani S, Pagani M.
Front Immunol (2015) 6:175

Direct and high throughput (HT) interactions on the ribosomal surface by iRIA.
Pesce E, Minici C, Babetaler J, Hurt E, Degano M, Calamita P, Biffo S.
Sci Rep (2015) 5:15401

The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4.
Ranzani V, Rossetti G, Panzeri I, Arrigoni A, Bonnal RJ, Curti S, Gruarin P, Provasi E, Sugliano E, Marconi M, De Francesco R, Geginat J, Bodega B, Abrignani S, Pagani M.
Nat Immunol (2015) 16:318-325

Eukaryotic translation initiation factor 6 is a novel regulator of reactive oxygen species-dependent megakaryocyte maturation.
Ricciardi S, Miluzio A, Brina D, Clarke K, Bonomo M, Aiolfi R, Guidotti LG, Falciani F, Biffo S.
J Thromb Haemost (2015) 13:2108-18

A new mouse avatar model of non-small cell lung cancer.
Russo MV, Faversani A, Gatti S, Ricca D, Del Gobbo A, Ferrero S, Palleschi A, Vaira V, Bosari S.
Front Oncol (2015) 5:52

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth.
Zanconato F, Forcato M, Battilana G, Azzolin L, Quaranta E, Bodega B, Rosato A, Bicciato S, Cordenonsi M, Piccolo S.
Nat Cell Biol (2015) 17:1218-27

Enhancement of Muscle T Regulatory Cells and Improvement of Muscular Dystrophic Process in mdx Mice by Blockade of Extracellular ATP/P2X Axis.
Gazzerro E, Baldassari S, Assereto S, Fruscione F, Pistorio A, Panicucci C, Volpi S, Perruzza L, Fiorillo C, Minetti C, Traggiai E, Grassi F, Bruno C.
Am J Pathol. (2015); 185(12):3349-60.

 

 

 

 

 

2014

Absence of a role for interleukin-13 in inflammatory bowel disease.
Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque SS, Ghanbari A, Joe-Njoku I, Giuffrida P, Rovedatti L, Geginat J, Corazza GR, MacDonald TT.
Eur J Immunol (2014) 44:370-85

Repetitive elements dynamics in cell identity programming, maintenance and disease.
Bodega B, Orlando V.
Curr Opin Cell Biol (2014) 31:67-73

Third trimester NG2-positive amniotic fluid cells are effective in improving repair in spinal cord injury.
Bottai D, Scesa G, Cigognini D, Adami R, Nicora E, Abrignani S, Di Giulio AM, Gorio A.
Exp Neurol (2014) 254:121-33

The association of IL28B genotype with the histological features of chronic hepatitis C is HCV genotype dependent.
D’Ambrosio R, Aghemo A, De Francesco R, Rumi MG, Galmozzi E, De Nicola S, Cheroni C, Clark PJ, Ronchi G, Lampertico P, Colombo M.
Int J Mol Sci (2014) 15:7213-24

Serum microRNAs as Biomarkers of Human Lymphocyte Activation in Health and Disease.
de Candia P, Torri A, Pagani M, Abrignani S.
Front Immunol (2014) 5:43

Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C.
De Nicola S, Dongiovanni P, Aghemo A, Cheroni C, D’Ambrosio R, Pedrazzini M, Marabita F, Donnici L, Maggioni M, Fargion S, Colombo M, De Francesco R, Valenti L.
PLoS One (2014) 9:e106022

Interleukin 28B genotype and insulin resistance in chronic hepatitis C patients.
Degasperi E, Valenti L, Aghemo A, De Francesco R, Rumi M, Soffredini R, Donnici L, Cheroni C, Fargion S, Zanoni V, Orsi E, Colombo M.
Antivir Ther (2014) 19:747-53

iNKT-cell help to B cells: a cooperative job between innate and adaptive immune responses.
Dellabona P, Abrignani S, Casorati G.
Eur J Immunol (2014) 44:2230-7

In vitro antibiofilm activity of bioactive glass S53P4.
Drago L, Vassena C, Fenu S, De Vecchi E, Signori V, De Francesco R, Romano CL.
Future Microbiol (2014) 9:593-601

Plasticity of human CD4 T cell subsets.
Geginat J, Paroni M, Maglie S, Alfen JS, Kastirr I, Gruarin P, De Simone M, Pagani M, Abrignani S.
Front Immunol (2014) 5:630

A proteomic approach to investigate AuNPs effects in Balb/3T3 cells.
Gioria S, Chassaigne H, Carpi D, Parracino A, Meschini S, Barboro P, Rossi F.
Toxicol Lett (2014) 228:111-26

IL-21 is a central memory T cell-associated cytokine that inhibits the generation of pathogenic Th1/17 effector cells.
Kastirr I, Maglie S, Paroni M, Alfen JS, Nizzoli G, Sugliano E, Crosti MC, Moro M, Steckel B, Steinfelder S, Stolzel K, Romagnani C, Botti F, Caprioli F, Pagani M, Abrignani S, Geginat J.
J Immunol (2014) 193:3322-31

Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors.
McGivern DR, Masaki T, Williford S, Ingravallo P, Feng Z, Lahser F, Asante-Appiah E, Neddermann P, De Francesco R, Howe AY, Lemon SM.
Gastroenterology (2014) 147:453-62 e7

The characterization of a novel monoclonal antibody against CD93 unveils a new antiangiogenic target.
Orlandini M, Galvagni F, Bardelli M, Rocchigiani M, Lentucci C, Anselmi F, Zippo A, Bini L, Oliviero S.
Oncotarget (2014) 5:2750-60

Diet composition transiently modulates proliferative and potency features of human cord blood-derived mesenchymal stem cells.
Ragni E, Parazzi V, Crosti M, Moro M, Giordano R, Lazzari L.
Int J Biochem Cell Biol (2014) 55:269-78

NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase IIIalpha complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes.
Reghellin V, Donnici L, Fenu S, Berno V, Calabrese V, Pagani M, Abrignani S, Peri F, De Francesco R, Neddermann P.
Antimicrob Agents Chemother (2014) 58:7128-40

Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis.
Selmi C, Cavaciocchi F, Lleo A, Cheroni C, De Francesco R, Lombardi SA, De Santis M, Meda F, Raimondo MG, Crotti C, Folci M, Zammataro L, Mayo MJ, Bach N, Shimoda S, Gordon SC, Miozzo M, Invernizzi P, Podda M, Scavelli R, Martin MR, Seldin MF, Lasalle JM, Gershwin ME.
Front Immunol (2014) 5:128

Photodynamic antibacterial and antibiofilm activity of RLP068/Cl against Staphylococcus aureus and Pseudomonas aeruginosa forming biofilms on prosthetic material.
Vassena C, Fenu S, Giuliani F, Fantetti L, Roncucci G, Simonutti G, Romano CL, De Francesco R, Drago L.
Int J Antimicrob Agents (2014) 44:47-55

Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking.
Wang H, Perry JW, Lauring AS, Neddermann P, De Francesco R, Tai AW.
Gastroenterology (2014) 146:1373-85 e1-11

Why is it so difficult to develop a hepatitis C virus preventive vaccine?
Zingaretti C, De Francesco R, Abrignani S.
Clin Microbiol Infect (2014) 20 Suppl 5:103-9

 

 

 

 

 

 

2013

New horizons in hepatitis C antiviral therapy with direct-acting antivirals.
Aghemo A, De Francesco R.
Hepatology (2013) 58:428-38

Cirrhosis and rapid virological response to peginterferon plus ribavirin determine treatment outcome in HCV-1 IL28B rs12979860 CC patients.
Aghemo A, Degasperi E, Rumi MG, Galmozzi E, Valenti L, De Francesco R, De Nicola S, Cheroni C, Grassi E, Colombo M.
Biomed Res Int (2013) 2013:580796

 

Reduction of CD68+ macrophages and decreased IL-17 expression in intestinal mucosa of patients with inflammatory bowel disease strongly correlate with endoscopic response and mucosal healing following infliximab therapy.
Caprioli F, Bose F, Rossi RL, Petti L, Vigano C, Ciafardini C, Raeli L, Basilisco G, Ferrero S, Pagani M, Conte D, Altomare G, Monteleone G, Abrignani S, Reali E.
Inflamm Bowel Dis (2013) 19:729-39

 

Intracellular modulation, extracellular disposal and serum increase of MiR-150 mark lymphocyte activation.
de Candia P, Torri A, Gorletta T, Fedeli M, Bulgheroni E, Cheroni C, Marabita F, Crosti M, Moro M, Pariani E, Romano L, Esposito S, Mosca F, Rossetti G, Rossi RL, Geginat J, Casorati G, Dellabona P, Pagani M, Abrignani S.
PLoS One (2013) 8:e75348

 

Hepatitis C virus-specific directly acting antiviral drugs.
Delang L, Neyts J, Vliegen I, Abrignani S, Neddermann P, De Francesco R.
Curr Top Microbiol Immunol (2013) 369:289-320

 

The CD4-centered universe of human T cell subsets.
Geginat J, Paroni M, Facciotti F, Gruarin P, Kastirr I, Caprioli F, Pagani M, Abrignani S.
Semin Immunol (2013) 25:252-62

 

IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B.
Lampertico P, Vigano M, Cheroni C, Facchetti F, Invernizzi F, Valveri V, Soffredini R, Abrignani S, De Francesco R, Colombo M.
Hepatology (2013) 57:890-6

 

A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans.
Law JL, Chen C, Wong J, Hockman D, Santer DM, Frey SE, Belshe RB, Wakita T, Bukh J, Jones CT, Rice CM, Abrignani S, Tyrrell DL, Houghton M.
PLoS One (2013) 8:e59776

 

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses.
Nizzoli G, Krietsch J, Weick A, Steinfelder S, Facciotti F, Gruarin P, Bianco A, Steckel B, Moro M, Crosti M, Romagnani C, Stolzel K, Torretta S, Pignataro L, Scheibenbogen C, Neddermann P, De Francesco R, Abrignani S, Geginat J.
Blood (2013) 122:932-42

 

Role of microRNAs and long-non-coding RNAs in CD4(+) T-cell differentiation.
Pagani M, Rossetti G, Panzeri I, de Candia P, Bonnal RJ, Rossi RL, Geginat J, Abrignani S.
Immunol Rev (2013) 253:82-96

 

 

 

 

 

 

 

 

2012

Multi high-throughput approach for highly selective identification of vaccine candidates: the Group A Streptococcus case.
Bensi G, Mora M, Tuscano G, Biagini M, Chiarot E, Bombaci M, Capo S, Falugi F, Manetti AG, Donato P, Swennen E, Gallotta M, Garibaldi M, Pinto V, Chiappini N, Musser JM, Janulczyk R, Mariani M, Scarselli M, Telford JL, Grifantini R, Norais N, Margarit I, Grandi G.
Mol Cell Proteomics (2012) 11:M111 015693

 

Metabolism of phosphatidylinositol 4-kinase IIIalpha-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity.
Bianco A, Reghellin V, Donnici L, Fenu S, Alvarez R, Baruffa C, Peri F, Pagani M, Abrignani S, Neddermann P, De Francesco R.
PLoS Pathog (2012) 8:e1002576

 

Biogem: an effective tool-based approach for scaling up open source software development in bioinformatics.
Bonnal RJ, Aerts J, Githinji G, Goto N, MacLean D, Miller CA, Mishima H, Pagani M, Ramirez-Gonzalez R, Smant G, Strozzi F, Syme R, Vos R, Wennblom TJ, Woodcroft BJ, Katayama T, Prins P.
Bioinformatics (2012) 28:1035-7

 

Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4.
De Nicola S, Aghemo A, Rumi MG, Galmozzi E, Valenti L, Soffredini R, De Francesco R, Prati GM, D’Ambrosio R, Cheroni C, Donato MF, Colombo M.
Hepatology (2012) 55:336-42

 

Surface interactome in Streptococcus pyogenes.
Galeotti CL, Bove E, Pezzicoli A, Nogarotto R, Norais N, Pileri S, Lelli B, Falugi F, Balloni S, Tedde V, Chiarot E, Bombaci M, Soriani M, Bracci L, Grandi G, Grifantini R.
Mol Cell Proteomics (2012) 11:M111 015206

 

Identification of new hematopoietic cell subsets with a polyclonal antibody library specific for neglected proteins.
Moro M, Crosti M, Creo P, Gallina P, Curti S, Sugliano E, Scavelli R, Cattaneo D, Canidio E, Marconi M, Rebulla P, Sarmientos P, Viale G, Pagani M, Abrignani S.
PLoS One (2012) 7:e34395

 

Circulating hepatitis B surface antigen particles carry hepatocellular microRNAs.
Novellino L, Rossi RL, Bonino F, Cavallone D, Abrignani S, Pagani M, Brunetto MR.
PLoS One (2012) 7:e31952

 

Development of an influenza virus protein array using Sortagging technology.
Sinisi A, Popp MW, Antos JM, Pansegrau W, Savino S, Nissum M, Rappuoli R, Ploegh HL, Buti L.
Bioconjug Chem (2012) 23:1119-26

 

Follicular helper NKT cells induce limited B cell responses and germinal center formation in the absence of CD4(+) T cell help.
Tonti E, Fedeli M, Napolitano A, Iannacone M, von Andrian UH, Guidotti LG, Abrignani S, Casorati G, Dellabona P.
J Immunol (2012) 188:3217-22

 

Identification of new autoantigens by protein array indicates a role for IL4 neutralization in autoimmune hepatitis.
Zingaretti C, Arigo M, Cardaci A, Moro M, Crosti M, Sinisi A, Sugliano E, Cheroni C, Marabita F, Nogarotto R, Bonnal RJ, Marcatili P, Marconi M, Zignego A, Muratori P, Invernizzi P, Colombatto P, Brunetto M, Bonino F, De Francesco R, Geginat J, Pagani M, Muratori L, Abrignani S, Bombaci M.
Mol Cell Proteomics (2012) 11:1885-97

 

 

 

 

 

 

 

 

2011

Dual role of anti-TNF therapy: enhancement of TCR-mediated T cell activation in peripheral blood and inhibition of inflammation in target tissues.
Bose F, Raeli L, Garutti C, Frigerio E, Cozzi A, Crimi M, Caprioli F, Scavelli R, Altomare G, Geginat J, Abrignani S, Reali E.
Clin Immunol (2011) 139:164-76

 

Substantial histone reduction modulates genomewide nucleosomal occupancy and global transcriptional output.
Celona B, Weiner A, Di Felice F, Mancuso FM, Cesarini E, Rossi RL, Gregory L, Baban D, Rossetti G, Grianti P, Pagani M, Bonaldi T, Ragoussis J, Friedman N, Camilloni G, Bianchi ME, Agresti A.
PLoS Biol (2011) 9:e1001086

 

Nutritional limitation sensitizes mammalian cells to GSK-3beta inhibitors and leads to growth impairment.
de Candia P, Minopoli G, Verga V, Gargiulo A, Vanoni M, Alberghina L.
Am J Pathol (2011) 178:1814-23

 

A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dolle P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A.
PLoS Biol (2011) 9:e1000582

 

A novel polyclonal antibody library for expression profiling of poorly characterized, membrane and secreted human proteins.
Grifantini R, Pagani M, Pierleoni A, Grandi A, Parri M, Campagnoli S, Pileri P, Cattaneo D, Canidio E, Pontillo A, De Camilli E, Bresciani A, Marinoni F, Pedrazzoli E, Nogarotto R, Abrignani S, Viale G, Sarmientos P, Grandi G.
J Proteomics (2011) 75:532-47

 

Genetic variation in the interleukin-28B gene is not associated with fibrosis progression in patients with chronic hepatitis C and known date of infection.
Marabita F, Aghemo A, De Nicola S, Rumi MG, Cheroni C, Scavelli R, Crimi M, Soffredini R, Abrignani S, De Francesco R, Colombo M.
Hepatology (2011) 54:1127-34

 

Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase.
Narjes F, Crescenzi B, Ferrara M, Habermann J, Colarusso S, Ferreira Mdel R, Stansfield I, Mackay AC, Conte I, Ercolani C, Zaramella S, Palumbi MC, Meuleman P, Leroux-Roels G, Giuliano C, Fiore F, Di Marco S, Baiocco P, Koch U, Migliaccio G, Altamura S, Laufer R, De Francesco R, Rowley M.
J Med Chem (2011) 54:289-301

 

Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b.
Rossi RL, Rossetti G, Wenandy L, Curti S, Ripamonti A, Bonnal RJ, Birolo RS, Moro M, Crosti MC, Gruarin P, Maglie S, Marabita F, Mascheroni D, Parente V, Comelli M, Trabucchi E, De Francesco R, Geginat J, Abrignani S, Pagani M.
Nat Immunol (2011) 12:796-803

 

Immunization of human volunteers with hepatitis C virus envelope glycoproteins elicits antibodies that cross-neutralize heterologous virus strains.
Stamataki Z, Coates S, Abrignani S, Houghton M, McKeating JA.
J Infect Dis (2011) 204:811-3

 

Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells.
Steinfelder S, Floess S, Engelbert D, Haeringer B, Baron U, Rivino L, Steckel B, Gruetzkau A, Olek S, Geginat J, Huehn J, Hamann A.
Blood (2011) 117:2839-46

 

 

 

 

 

 

 

2010

Reliable resequencing of the human dystrophin locus by universal long polymerase chain reaction and massive pyrosequencing.
Bonnal RJ, Severgnini M, Castaldi A, Bordoni R, Iacono M, Trimarco A, Torella A, Piluso G, Aurino S, Condorelli G, De Bellis G, Nigro V.
Anal Biochem (2010) 406:176-84

 

Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults.
Frey SE, Houghton M, Coates S, Abrignani S, Chien D, Rosa D, Pileri P, Ray R, Di Bisceglie AM, Rinella P, Hill H, Wolff MC, Schultze V, Han JH, Scharschmidt B, Belshe RB.
Vaccine (2010) 28:6367-73

 

BioRuby: bioinformatics software for the Ruby programming language.
Goto N, Prins P, Nakao M, Bonnal R, Aerts J, Katayama T.
Bioinformatics (2010) 26:2617-9

 

RSSsite: a reference database and prediction tool for the identification of cryptic Recombination Signal Sequences in human and murine genomes.
Merelli I, Guffanti A, Fabbri M, Cocito A, Furia L, Grazini U, Bonnal RJ, Milanesi L, McBlane F.
Nucleic Acids Res (2010) 38:W262-7

 

Characterization of nucleotide misincorporation patterns in the iceman’s mitochondrial DNA.
Olivieri C, Ermini L, Rizzi E, Corti G, Bonnal R, Luciani S, Marota I, De Bellis G, Rollo F.
PLoS One (2010) 5:e8629

 

Mechanism of hepatitis C virus RNA polymerase inhibition with dihydroxypyrimidines.
Powdrill MH, Deval J, Narjes F, De Francesco R, Gotte M.
Antimicrob Agents Chemother (2010) 54:977-83

 

Characterization of antibodies induced by vaccination with hepatitis C virus envelope glycoproteins.
Ray R, Meyer K, Banerjee A, Basu A, Coates S, Abrignani S, Houghton M, Frey SE, Belshe RB.
J Infect Dis (2010) 202:862-6

 

CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function.
Rivino L, Gruarin P, Haringer B, Steinfelder S, Lozza L, Steckel B, Weick A, Sugliano E, Jarrossay D, Kuhl AA, Loddenkemper C, Abrignani S, Sallusto F, Lanzavecchia A, Geginat J.
J Exp Med (2010) 207:565-77

 

Biology of interleukin-10.
Sabat R, Grutz G, Warszawska K, Kirsch S, Witte E, Wolk K, Geginat J.
Cytokine Growth Factor Rev (2010) 21:331-44

 

Streptococcus pyogenes SpyCEP: a chemokine-inactivating protease with unique structural and biochemical features.
Zingaretti C, Falugi F, Nardi-Dei V, Pietrocola G, Mariani M, Liberatori S, Gallotta M, Tontini M, Tani C, Speziale P, Grandi G, Margarit I.
FASEB J (2010) 24:2839-48

 

 

 

 

 

2009

B cell helper assays.
Abrignani S, Tonti E, Casorati G, Dellabona P.
Methods Mol Biol (2009) 514:15-26

The mitochondrial genome, a growing interest inside an organelle.
Crimi M, Rigolio R.
Int J Nanomedicine (2008) 3:51-7

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